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A complete of three % of active material is excreted in urine as unchanged active compound. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, that are more metabolised by conjugation. Consequently, active material metabolism mediated by cytochrome P450 techniqu